Metabolism of sennosides by intestinal flora.

Metabolism of deoxycorticosterone by human fecal flora.

21-Dehydroxylation, a feature of metabolism of corticoids in humans, was observed in mixed cultures of fecal flora of normal individuals on a Western diet. The model substrate, 11-deoxycorticosterone (DOC), was metabolized to 3alpha-21-dihydroxy-5beta-pregnan-20-one (THDOC), 3alpha-hydroxy-5beta-pregnan20-one (pregnanolone), and to two unidentified structures, metabolites X and Y. DOC was not m...

Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora.

In the course of studies on the metabolism of active components of Huangqin-Tang by human intestinal flora (HIF), Huangqin-Tang and all individual herbs in the decoctions were incubated with a human fecal suspension separately. By using a high-performance liquid chromatographic (HPLC) method which was previously established in our laboratory, the metabolites in both the compound prescription an...

The roles of intestinal flora and intestinal function on vitamin K metabolism.

Intestinal Flora and Nutrition

Sir,?There is one aspect of study in nutrition which does not yet appear to have been accorded its true value. I refer to the part played by the organisms living inside the alimentary tract of man. To the majority studies on nutrition end at the stage at which the food is Swallowed. Others, more exact, define conditions in which absorption of the ultimate products of digestion is disturbed as f...

Intestinal flora and diet

The topics discussed at the WIRM-V meeting were very broad and interesting, covering a wide field in immunology. Since it is impossible to summarize everything, I will discuss the influence of diet and intestinal flora on immune responses, as this was a recurrent subject throughout the meeting. I will summarize a few presentations (given by E.G. Pamer, C. MacKay, D.R. Littman, Y. Belkaid, R. Ma...